The development of a reference database with the Topcon 3D OCT-1 Maestro

AI Generated Summary*

Reference limits for a spectral domain OCT platform were built from 399 healthy eyes at seven US clinical sites; 504 were screened, and mean age was 46.3 years (18 to 88), 43% male. Non-crossing quantile regressions covarying age, plus disc area for optic nerve measures, generated 1st through 99th percentile limits. Averages from the 12 by 9 mm wide scan were roughly 237 μm foveal thickness, 71 μm ganglion cell plus inner plexiform layer, 106 μm ganglion cell complex and 105 μm circumpapillary nerve fiber layer, similar to 6 by 6 mm scans. Ganglion cell measures thinned with age, while disc area strongly influenced nerve fiber layer thickness. Values resembled published ranges, though the report warns against swapping devices.

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