Six-Year Rate of Visual Field Progression in the Laser in Glaucoma and Ocular Hypertension Trial

AI Generated Summary*

Post hoc analysis of the LiGHT randomized trial compared visual field mean deviation (MD) decline over six years in 710 patients (one better eye each; 354 randomized to laser first) with newly diagnosed ocular hypertension or open-angle glaucoma. A Bayesian hierarchical mixed model separated true progression from perimetric learning and noise. Estimated MD loss was -0.37 dB/year with drops first and -0.26 dB/year with laser first (P = 0.007), roughly 29% slower. Median follow-up IOP was similar (16.1 versus 16.8 mmHg). By severity, only mild glaucoma reached significance (P = 0.035). Truncating at surgery or switching, and using mean pattern deviation, gave consistent results; worse-eye analysis showed no significant difference.

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