Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

AI Generated Summary*

Spectral domain OCT data from 40 studies (5776 multiple sclerosis eyes, 1697 healthy control eyes) were pooled by random effects meta-analysis to establish which retinal layers atrophy. Eyes were classed as controls, MS with prior optic neuritis (MSON), or MS without it (MSNON). Peripapillary RNFL was 20.10 µm thinner in MSON and 7.41 µm thinner in MSNON eyes than in controls; macular ganglion cell plus inner plexiform layer (GCIPL) deficits were 16.42 µm and 6.31 µm respectively. Longitudinally, peripapillary RNFL thinned by 0.36 to 1.49 µm annually. The inner nuclear layer was slightly thicker after optic neuritis (0.77 µm); outer layers did not differ from controls. Peripapillary RNFL and macular GCIPL emerged as the most robust neurodegeneration markers.

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