Retinal BioAge is associated with indicators of cardiovascular-kidney-metabolic syndrome in UK and US populations

AI Generated Summary*

A deep learning estimate of biological age from retinal photographs was tested against cardiovascular, kidney and metabolic markers in two cross-sectional cohorts aged 41 to 70: 5,476 UK Biobank participants from a general population and 9,786 EyePACS patients with diabetes, mostly Hispanic/Latino. Within five-year age bands, top and bottom quartiles of BioAgeGap (estimated minus chronological age) were compared. In UK Biobank, the top quartile had systolic pressure 8.01 mmHg higher and more hypertension (51.3% versus 30.0%), kidney disease (5.9% versus 3.9%) and diabetes (2.9% versus 1.5%). In EyePACS, HbA1c was 0.73% higher, eGFR 3.47 mL/min/1.73 m2 lower, kidney disease 35.8% versus 20.8% and any diabetic retinopathy 57.8% versus 9.4%, whereas obesity was less frequent in the top quartile.

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