Retinal age gap as a predictive biomarker of future risk of Parkinson's disease

AI Generated Summary*

In UK Biobank, an algorithm built on 19,200 retinal photographs from 11,052 people reporting no prior disease estimated age from the fundus, and its gap from actual age was tracked in 35,834 adults free of Parkinson's disease at enrolment (mean age 56.7 years, 55.7% female). Sixty-three cases emerged over a median of 5.83 years. With confounders controlled, each extra year of gap carried a 10% higher hazard (HR 1.10, 95% CI 1.01 to 1.20), and the top two quartiles showed hazard ratios of 2.66 and 4.86 versus the lowest. Retinal age discriminated five-year risk about as well as age, sex and smoking (AUC 0.708 versus 0.717), findings the investigators describe as needing further validation.

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