Repeatability of Microperimetry in Areas of Retinal Pigment Epithelium and Photoreceptor Loss in Geographic Atrophy Supported by Artificial Intelligence–Based Optical Coherence Tomography Biomarker Quantification

AI Generated Summary*

Twenty eyes of 20 patients with geographic atrophy (mean age 77) took two consecutive microperimetry sessions on each of two devices, a mesopic MAIA and a photopic MP3, using a 45-point grid. Each test point was registered to same-day OCT, where deep learning tools mapped RPE loss, photoreceptor integrity loss, drusen, hyperreflective foci and photoreceptor thickness. Overall test-retest coefficients of repeatability were nearly equal (±6.57 dB MAIA, ±6.59 dB MP3). Photoreceptor loss was linked to greater variability on both devices, while RPE loss (±10.99 vs ±5.34 dB without it) and hyperreflective foci were linked to it on MP3 only. Within-device correlation was 0.94, mean between-device 0.83, and fixation stability was unaffected by device, run order or foveal sparing.

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