Quantitative Comparison of Automated OCT and Conventional FAF-Based Geographic Atrophy Measurements in the Phase 3 OAKS/DERBY Trials

AI Generated Summary*

Post hoc analysis of the OAKS and DERBY pegcetacoplan trials compared deep learning quantification of retinal pigment epithelium (RPE) and ellipsoid zone (EZ) loss on Spectralis OCT against reading center fundus autofluorescence (FAF) delineation of geographic atrophy. Cohorts comprised 365 and 354 patients at baseline, 279 and 269 at month 24. FAF area and OCT RPE loss correlated at r 0.96 to 0.97 throughout, with FAF values roughly 0.9 to 1.3 mm² larger. EZ loss exceeded FAF area by about 2 to 3 mm² and correlated less strongly (r 0.69 to 0.79). For RPE loss, change from baseline correlated weakly to moderately early, reaching 0.85 to 0.89 at month 24. Automated OCT was considered suitable for atrophy monitoring.

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