Oculomics analysis in multiple sclerosis: current ophthalmic clinical and imaging biomarkers

AI Generated Summary*

Screening 917 records under PRISMA methods yielded 104 articles on ocular biomarkers of multiple sclerosis. Optical coherence tomography dominates: retinal nerve fibre layer reductions average 46% in affected eyes, 28% versus the fellow eye, and 26% in unaffected eyes versus controls, while macular volume was 11% lower after optic neuritis than in controls. Recent OCT work suggests ganglion cell and inner plexiform layer thickness outperforms rim width and peripapillary nerve fibre measures in anticipating visual deficits, and its loss is greater in secondary progressive than relapsing remitting disease. Angiography vessel density, tear proteins, corneal nerves, pupil responses, evoked potentials, low contrast acuity and saccadic abnormalities are surveyed, with machine learning proposed to complement costly, invasive MRI and spinal fluid testing.

*This summary was generated by AI and is published unedited. Oku does not alter these summaries. It may contain errors or omissions and is provided for general informational purposes only. Oku does not guarantee its accuracy, completeness, or reliability. For authoritative information, please refer to the original, peer-reviewed article.