Monitoring der Progression von geografischer Atrophie in der optischen Kohärenztomographie

AI Generated Summary*

German-language overview from a Vienna group arguing that optical coherence tomography (OCT) with AI-based analysis suits monitoring of geographic atrophy as the first therapy nears approval. Manually annotated OCT volumes covered 100 routine patients and 113 from the phase 2 FILLY pegcetacoplan trial (11,074 B-scans); lesion areas on OCT and fundus autofluorescence correlated at 0.97. Treated patients lost retinal pigment epithelium (RPE) more slowly than untreated ones (p=0.014), as did photoreceptors (p=0.017), and photoreceptor loss exceeded RPE loss (p<0.001). Automated segmentation reached Dice values above 0.9 for RPE loss and 0.8 for photoreceptor loss. High baseline photoreceptor/RPE loss ratio flagged faster growth (p=0.006) and reportedly better response; heat maps showed quicker progression near the fovea and where photoreceptors were thinner.

*This summary was generated by AI and is published unedited. Oku does not alter these summaries. It may contain errors or omissions and is provided for general informational purposes only. Oku does not guarantee its accuracy, completeness, or reliability. For authoritative information, please refer to the original, peer-reviewed article.