Fundus Autofluorescence and Optical Coherence Tomography Biomarkers Associated with the Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration

AI Generated Summary*

Growth of geographic atrophy in age-related macular degeneration was examined against graded and automatically quantified imaging features. Across 1062 visits, 181 eyes of 100 patients were prospectively imaged with spectral-domain OCT and fundus autofluorescence (FAF). Hyperreflective foci (HRF) were counted by a validated deep learning tool, and FAF images graded for pattern, subretinal drusenoid deposits (SDD), lesion configuration and enlargement. Mixed models showed FAF pattern significantly associated with progression (p < 0.001) and SDD with faster growth (p = 0.005). Higher HRF concentration only trended toward faster progression (p = 0.072) but interacted significantly with FAF pattern (p = 0.01). Fellow eye status had no significant effect, and diffuse-trickling eyes showed the highest HRF concentrations.

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