Extended Optical Treatment versus Early Patching with an Intensive Patching Regimen in Children with Amblyopia in Europe (Eupatch): A Multicentre, Randomised Controlled Trial

AI Generated Summary*

Children aged 3 to 8 years with untreated amblyopia from anisometropia, strabismus or both were randomised across 30 hospitals in five European countries to either 18 weeks of glasses alone before patching or 3 weeks of glasses before patching, with intensive patching of 10 hours daily, six days weekly, in both arms. Of 334 eligible participants, 317 were analysed at 12 weeks of patching. Success, defined as an interocular acuity gap of 0.20 logMAR or less, was reached by 67% of early patching children versus 54% of the extended glasses group (p=0.019). In a post-hoc analysis, younger children with milder amblyopia were likeliest to respond to glasses alone. No serious treatment-related adverse events occurred.

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