Evaluation of macular thickness and volume tested by optical coherence tomography as biomarkers for Alzheimer’s disease in a memory clinic

AI Generated Summary*

Optical coherence tomography macular measures were assessed cross-sectionally as possible Alzheimer's markers in 930 memory clinic patients recruited consecutively, eye disease excluded: 414 cognitively healthy, 192 with probable amnestic mild cognitive impairment, 324 with probable Alzheimer's disease. Analysis covered right eyes only: thickness, volume, layers and ETDRS sectors. After adjustment for age, education, sex and scan quality, groups matched on total thickness (p=0.564), ganglion cell layer (p=0.267), retinal nerve fibre layer (p=0.574) and thickness with volume (p=0.380). Superior and nasal inner ring sectors ran roughly 4 μm higher in controls than dementia cases (p=0.040 each), though this faded after multiple comparison correction. Age outweighed diagnosis in explaining variability, leaving macular thickness unpromising as a memory clinic biomarker pending longitudinal work.

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