Dynamic Pupillary Response in Multiple Sclerosis Patients with and without Optic Neuritis

AI Generated Summary*

Pupillary light responses were compared across 24 healthy eyes, 22 eyes from multiple sclerosis (MS) patients with no optic neuritis history, and 13 from MS patients whose neuritis had resolved; groups matched on age, sex and corrected acuity. A pupillometry module built into a corneal topographer tracked diameter over 16 seconds of mesopic, photopic and scotopic light. Eyes without prior neuritis showed no significant difference from controls on any parameter. Those with previous neuritis had smaller constriction amplitude (40.71% versus 45.22%, p=0.01) and longer constriction latency (0.35 versus 0.26 s, p=0.03). No dilation measure reached significance, though the technique was judged poorly suited to dilation; reduced constriction left 9% and 12% of the MS groups short of 75% redilation.

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