Comparison of Optical Coherence Tomography vs. Fluorescein Angiography-Based Macular Neovascularization Classifications in Age-Related Macular Degeneration

AI Generated Summary*

Baseline fluorescein angiography (FA) and optical coherence tomography (OCT) images from 704 eyes in two anti-VEGF trials for neovascular age-related macular degeneration were graded by masked reading center experts, using Macular Photocoagulation Study definitions plus retinal angiomatous proliferation for FA and consensus nomenclature types 1, 2, mixed and 3 for OCT. Overall kappa reached 0.481, ranging from 0.271 (mixed) to 0.582 (type 1 versus occult), agreement the investigators judged too limited for OCT alone to replace FA. Automated segmentation showed significantly different intraretinal, subretinal and sub-RPE volumes across OCT types (p<0.0001); more intraretinal fluid was linked to slightly lower odds of concordance (OR 0.95), larger sub-RPE volume to higher odds (OR 1.17), with subretinal fluid showing no significant effect.

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