Combination of Orthokeratology Lens with 0.01% Atropine in Slowing Axial Elongation in Children with Myopia: A Randomized Double-Blinded Clinical Trial

AI Generated Summary*

A randomized, double-masked, placebo-controlled trial tested adding nightly 0.01% atropine to orthokeratology in myopic Chinese children. Sixty participants aged 8 to 12 (spherical equivalent -1.00 to -4.00 D), already wearing lenses for two months, were split equally between atropine and a blank vehicle; 53 were analyzed. Twelve-month axial growth was 0.10 ± 0.14 mm with the combination versus 0.20 ± 0.15 mm with lenses plus placebo (p = 0.01); the arms diverged significantly only during the first four-month interval. Pupil diameter rose 0.45 mm by four months with atropine, then plateaued; accommodative amplitude did not change significantly in either arm. Mild photophobia affected 13.3% of atropine and 10% of placebo recipients. The authors call the findings preliminary.

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