Baseline Predictors for Subretinal Fibrosis in Neovascular Age-Related Macular Degeneration

AI Generated Summary*

Forty-five treatment-naive eyes with neovascular age-related macular degeneration were followed for 12 months on an aflibercept treat-and-extend regimen to look for baseline signs of subretinal fibrosis. Fibrosis at month 12 was judged using color fundus photography, fluorescein angiography and polarization-sensitive OCT, with microperimetry settling one discordant case. Eight eyes (18%) developed fibrosis; these had worse baseline acuity (median 54 versus 74 ETDRS letters, p=0.001), and every one showed intraretinal fluid (versus 51%, p=0.014) and subretinal hyperreflective material (versus 54%, p=0.017). A subretinal lesion component, type 2 or mixed, was present in 88% of fibrotic eyes versus 8% of the rest. Among the 33 eyes with quantifiable angiography lesions, no vascular metric differed significantly, though this exploratory sample was small.

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