Association between retinal features from multimodal imaging and schizophrenia

AI Generated Summary*

Retinal images from 485 people with schizophrenia and 100,931 controls, all aged 40 or over and attending a London eye hospital, were analysed cross-sectionally in the AlzEye cohort, which links ophthalmic records to English hospital admissions, 2008 to 2018. Vascular measures and cup-disc ratio came from fundus photographs processed by two automated pipelines, and inner retinal thickness from OCT. Hypertension (83.9% vs 48.0%) and diabetes (75.1% vs 27.6%) were commoner in the schizophrenia group. Adjusting for age, sex, deprivation, comorbidities and image quality, the macular ganglion cell-inner plexiform layer was 4.05 microns thinner, remaining thinner in those without diabetes (3.99) and those under 55 (2.90). Adjusted nerve fibre layer thickness was similar, and most vascular differences reflected the comorbidities.

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