Anatomical Features can Affect OCT Measures Used for Clinical Decisions and Clinical Trial Endpoints

AI Generated Summary*

Among 396 healthy eyes in a normative dataset, circumpapillary retinal nerve fiber layer thickness tracked with fovea-to-disc distance, an axial length proxy from mirror position, and superior and inferior peak locations on the thickness curve. For at least one quadrant, each parameter correlated better with thickness than age or disc area, the factors already built into color coding; the superior peak correlated -0.42 with temporal thickness versus -0.24 for age. Fovea-to-disc distance and both peak locations separated eyes with flagged temporal quadrants from others (P below 0.001), while nothing distinguished flagged global values. Nasally shifted peaks accompanied thinner temporal quadrants, temporally shifted peaks thinner superior or inferior quadrants. Adding these factors to percentile adjustment is proposed, pending testing.

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