AlzEye: longitudinal record-level linkage of ophthalmic imaging and hospital admissions of 353 157 patients in London, UK

AI Generated Summary*

AlzEye is a retrospective cohort resource linking routinely collected retinal imaging from a London tertiary eye hospital with national hospital admissions records. It covers 353,157 patients aged 40 and over attending between January 2008 and April 2018; 53.9% were female, mean age 68.4 years. Among them, 186,651 had 1,337,711 admitted patient care episodes, with 12,022 patients coded for myocardial infarction, 11,735 for all-cause stroke and 13,363 for all-cause dementia. Imaging totalled 6,261,931 images from 154,830 patients across seven modalities and three vendors, led by colour photography and optical coherence tomography. Pseudonymised third-party linkage kept identifiers apart from admissions data. Coding validity and a comorbid hospital population are acknowledged limits, with nested case-control analyses of cardiovascular disease and dementia planned.

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