Agreement, repeatability, and reproducibility of quantitative retinal layer assessment using swept-source and spectral-domain optical coherence tomography in eyes with retinal diseases

AI Generated Summary*

Swept-source and spectral-domain OCT were compared for agreement and precision of layer thickness measurements in 25 healthy eyes and 26 eyes with retinal disease, including macular degeneration and epiretinal membrane. Three units of each type, one per operator, captured at least three wide and macular cube scans per eye. Full retinal, ganglion cell plus inner plexiform, and ganglion cell complex thicknesses were assessed. Mean between-device differences were under 6 μm and not significant. Repeatability limits did not exceed 7.6 μm for swept-source and 12.7 μm for spectral-domain; reproducibility limits reached 9.2 μm and 14.4 μm. In diseased eyes, coefficients of variation were at most 3.5%. Precision was lower with pathology, and the authors judged both systems reliable and interoperable.

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