A Systematic Prospective Comparison of Fluid Volume Evaluation Across OCT Devices Used in Clinical Practice

AI Generated Summary*

Forty eyes of 40 patients with neovascular AMD were imaged at one visit on four OCT platforms (three spectral domain, one swept source), giving 160 volumes. Intraretinal fluid, subretinal fluid and pigment epithelial detachment were segmented automatically, corrected by a trained reader and quantified in nanoliters. Intraclass correlations stayed above 0.93. At 1 mm, IRF and SRF did not differ significantly, standard deviations of paired differences reached 6, 4 and 10 nL respectively, and at least 95% of SRF differences fell within 10 nL, though PED differed for one pair. At 6 mm, the highest signal to noise system trended higher for IRF and PED, with some significant pairwise differences. Switching devices may shift measurements, agreement seeming better centrally.

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